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Bone marrow/allograft component therapy. A clinical trial
1Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts, USA.
American Journal of Orthopedics (Belle Mead, N.J.)
|January 1, 1995
Summary
Autogenous bone marrow/cancellous allograft offers a viable alternative for bone grafting in skeletal defects. This study found 100% clinical healing and 95% radiographic union with no complications, supporting its use.
Area of Science:
- Orthopedics
- Regenerative Medicine
- Biomaterials
Background:
- Skeletal defects necessitate bone grafting for healing, with autogenous iliac bone graft being the current standard.
- The development of bone graft substitutes is crucial for addressing limitations of autogenous grafts.
Purpose of the Study:
- To evaluate the efficacy of autogenous bone marrow/cancellous allograft as a substitute for iliac bone graft in patients with bony defects.
- To assess both clinical and radiographic outcomes following the use of this bone graft substitute.
Main Methods:
- A prospective study involving 19 consecutive patients with bony defects.
- Autogenous bone marrow/cancellous allograft was used as the bone graft substitute.
- Clinical and radiographic outcomes were monitored post-procedure.
Main Results:
- 100% of patients achieved clinical healing at the grafting site.
- 95% of patients demonstrated radiographic union.
- No surgical or postoperative complications were reported in any patient.
Conclusions:
- Autogenous bone marrow/cancellous allograft is a safe and effective alternative to autogenous iliac bone graft.
- This allograft substitute demonstrates high rates of clinical and radiographic success in treating skeletal defects.
- The findings support the use of bone marrow/allograft in orthopedic procedures requiring bone reconstruction.