DNA repair proteins
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J A Tainer1, M M Thayer, R P Cunningham
1Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037, USA.
Current Opinion in Structural Biology
|February 1, 1995
Abstract:
DNA repair proteins act to correct mutagenic and toxic DNA damage, which can lead to cancer, aging and death. These proteins and their mechanisms of action have been found to be widely conserved between species, often from bacteria to man. Structural and biochemical studies on several bacterial enzymes involved in direct reversal and base excision repair have provided insights into the molecular basis of the recognition of damaged DNA and have also highlighted the novel roles that transition metals play in DNA repair.