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Mortality in patients receiving renal replacement therapy, a single center study
A M Schrander-v d Meer1, J L van Saase, A P Roodvoets
1Kennemer Gasthuis, Haarlem, The Netherlands.
Clinical Nephrology
|March 1, 1995
Summary
Patients on renal replacement therapy (RRT) face high mortality, with cardiovascular issues being the leading cause of death. Young dialysis patients and men exhibit significantly higher standardized mortality rates compared to the elderly and women, respectively.
Area of Science:
- Nephrology
- Public Health
- Epidemiology
Background:
- Renal replacement therapy (RRT) is a critical intervention for end-stage kidney disease.
- Assessing mortality patterns in RRT patients is essential for understanding treatment outcomes and public health implications.
Purpose of the Study:
- To evaluate the mortality rates and patterns among patients undergoing renal replacement therapy (RRT) at the Kennemer Gasthuis Dialysis Centre.
- To compare the mortality of RRT patients with the general population and identify demographic factors influencing survival.
Main Methods:
- Retrospective analysis of 205 patients receiving RRT between January 1, 1986, and January 1, 1991.
- Calculation of Standardized Mortality Rate (SMR) and comparison with the general population of The Netherlands.
- Kaplan-Meier survival analysis to assess patient survival based on transplantability and start date of RRT.
Main Results:
- The overall mortality rate for RRT patients was significantly higher than the general population, with an SMR of 6.91.
- Cardiovascular disease was the most frequent cause of death; cessation of dialysis was requested by 38 patients.
- Younger patients (<50 years) had a markedly higher SMR (50.00) than older patients (7.19), and males had twice the SMR of females.
Conclusions:
- Renal replacement therapy is associated with a high overall mortality rate.
- Younger patients and males experience disproportionately higher mortality rates within the RRT population.
- While demographic factors indicate higher risk for certain groups, survival analyses did not consistently reflect these differences.