[Treatment of pediatric late stage neuroblastoma]

From 1960 to 1992, 62 children with late stage neuroblastoma (stage III-IV) were admitted to our hospital. 24 (1960-1982) treated with operation and routine chemotherapy all died in 24 months after operation. And in 38 (1983-1993) treated with operation and high dose chemotherapy (including auto-bone-marrow transplantation + three times dose VM26 + routine chemotherapy in 3 cases, high dose chemotherapy + resection of tumor + high dose chemotherapy + routine chemotherapy for 4 years in 27, and dumbbell neuroblastoma in 8), 24 cases (63.%) still lived up to now. In which 11 cases (28.9%) lived more than 5 years and other 13 cases middle survival stage was 26.9 months. The high chemotherapy couldn't be instead of operation but it might produce a favourable condition to radical operation and thereby increase the effect of the operation.