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Related Experiment Videos

[Kidney transplantation]

K Kanagawa1

  • 1Department of Urology, Asahikawa City Hospital, Japan.

[Hokkaido Igaku Zasshi] the Hokkaido Journal of Medical Science
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

Living-related kidney transplants using cyclosporine immunosuppression showed excellent patient survival rates. Graft survival was high, though chronic rejection remained a significant cause of graft loss in these renal transplant cases.

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Area of Science:

  • Nephrology and Immunology
  • Transplantation Medicine

Context:

  • Cyclosporine-based immunosuppression was utilized for living-related renal transplants between 1986 and 1994.
  • The study included recipients aged 4-48 years, with a majority on hemodialysis prior to transplantation.
  • Donors were primarily parents (87.3%) and siblings (12.7%) of the recipients.

Purpose:

  • To evaluate the outcomes of living-related renal transplantation under cyclosporine combination immunosuppression.
  • To analyze patient and graft survival rates, and identify causes of graft loss.
  • To compare outcomes with limited data from cadaveric renal transplants performed in the same period.

Summary:

  • 110 living-related renal transplants demonstrated high patient survival (95.7% at 5 years) and graft survival (77.8% at 5 years).

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  • Acute rejection occurred in 69.1% of patients, while chronic rejection (55%) was the leading cause of graft loss.
  • Limited cadaveric transplants (13) showed comparable short-term survival, highlighting the need for increased organ donation.

    • Impact:

    • Provides long-term survival data for cyclosporine-treated living-related renal transplants.
    • Identifies chronic rejection as a critical factor influencing graft longevity.
    • Underscores the importance of promoting organ donation systems to improve access to transplantation.