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Dopamine hypersensitivity in migraine: role in apomorphine syncope
1Department of Neurosciences B.B. Brodie, Headache Center, University of Cagliari, Italy.
Headache
|April 1, 1995
Summary
Hypersensitivity of the dopaminergic system may contribute to migraine pathogenesis. A patient experienced syncope after a low dose of apomorphine, suggesting this dopaminergic system hypersensitivity.
Area of Science:
- Neurology
- Pharmacology
Background:
- Migraine pathogenesis may involve dopaminergic system hypersensitivity.
- Apomorphine is a classical agonist of dopaminergic receptors.
Observation:
- A patient with migraine without aura experienced a syncopal episode.
- The episode occurred after administration of a very low dose of apomorphine.
Findings:
- The syncopal event in the patient suggests potential hypersensitivity of the dopaminergic system.
- Absence of cardiovascular risk factors supports this hypothesis.
Implications:
- This case report highlights a potential mechanism linking dopaminergic system function to migraine-related syncope.
- Further research into dopaminergic system sensitivity in migraine patients is warranted.