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Related Experiment Videos

Catecholaminergic effects of prolonged head-down bed rest

D S Goldstein1, J Vernikos, C Holmes

  • 1Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, Maryland 20892, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|March 1, 1995
PubMed
Summary

Head-down bed rest (HDBR) simulates weightlessness, revealing sustained sympathoinhibition of norepinephrine release. This response, despite decreased blood volume, may explain astronaut orthostatic intolerance.

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Area of Science:

  • Human physiology
  • Space medicine
  • Neuroendocrinology

Background:

  • Head-down bed rest (HDBR) models chronic weightlessness.
  • Understanding physiological responses to simulated microgravity is crucial for space exploration.

Purpose of the Study:

  • To investigate the effects of prolonged HDBR on catecholamine levels and sympathoneural activity in humans.
  • To determine if HDBR induces sustained changes in the sympathetic nervous system.

Main Methods:

  • Eight healthy volunteers underwent 2 weeks of HDBR.
  • Plasma catechol levels (norepinephrine, epinephrine, dopamine) were measured.
  • Urinary catechol excretion rates were analyzed throughout the study.

Main Results:

Keywords:
NASA Center HQSNASA Discipline CardiopulmonaryNon-NASA Center

Related Experiment Videos

  • HDBR led to decreased plasma and blood volumes, atriopeptin levels, and venous pressure.
  • Norepinephrine (NE) excretion significantly decreased by day 14 of HDBR.
  • Plasma NE levels showed variable, nonsignificant decreases; other catechol levels remained unchanged.

Conclusions:

  • HDBR induces sustained sympathoinhibition of norepinephrine release, turnover, and synthesis.
  • Hypovolemia during HDBR may mask sympathoinhibition in plasma catechol measurements.
  • This sympathoinhibition might contribute to orthostatic intolerance observed in astronauts post-flight.