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Breastfeeding and sertraline: a 24-hour analysis
L L Altshuler1, V K Burt, M McMullen
1UCLA Neuropsychiatric, USA.
The Journal of Clinical Psychiatry
|June 1, 1995
Summary
Sertraline levels in breast milk fluctuate significantly. Infant serum levels of sertraline and nortriptyline were undetectable, suggesting minimal infant exposure during breastfeeding.
Area of Science:
- Pharmacology
- Neonatal Health
- Psychiatry
Background:
- Limited data exists on antidepressant levels in breast milk and their effects on breastfed neonates.
- This presents a challenge for breastfeeding mothers requiring psychotropic medication.
Observation:
- Sertraline levels in breast milk were monitored over 24 hours in a breastfeeding patient.
- Infant and maternal serum samples were analyzed for sertraline and nortriptyline levels.
Findings:
- Breast milk sertraline levels peaked 5-9 hours post-ingestion and were lowest shortly before and after dosing.
- Infant serum levels for both sertraline and nortriptyline were undetectable.
Implications:
- Sertraline transfer to the infant via breast milk appears minimal, with no observed adverse effects.
- Future research should include metabolite analysis to fully assess infant risk.