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Prolonged bleeding time during ciprofloxacin therapy

H L Pilmore1, R J Walker

  • 1Department of Medicine, University of Otago Medical School, Dunedin, New Zealand.

Journal of Clinical Pharmacy and Therapeutics
|February 1, 1995
PubMed
Summary
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Ciprofloxacin, a common antibiotic, rarely causes bleeding issues. A case study suggested a link, but further research in healthy volunteers showed no effect on bleeding time.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Antibiotic Research

Background:

  • Ciprofloxacin is a broad-spectrum quinolone antibiotic.
  • Common side effects include gastrointestinal and musculoskeletal issues.
  • No prior documentation of bleeding abnormalities or coagulation alterations exists.

Observation:

  • A single patient case suggested ciprofloxacin might idiosyncratically prolong bleeding time.
  • A subsequent rechallenge in the same patient did not replicate the prolonged bleeding.
  • Investigation involved 10 healthy volunteers to assess ciprofloxacin's effect on bleeding parameters.

Findings:

  • The case report indicated a potential, albeit idiosyncratic, link between ciprofloxacin and prolonged bleeding.
  • Rechallenge and volunteer studies failed to confirm this association.

Related Experiment Videos

  • No significant alterations in bleeding parameters were observed in healthy volunteers after ciprofloxacin administration.

    • Implications:

    • Ciprofloxacin is unlikely to cause clinically significant bleeding issues in the general population.
    • Further investigation into rare idiosyncratic reactions may be warranted.
    • This study contributes to the safety profile understanding of fluoroquinolone antibiotics.