Proliferation of hepatocytes
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Updated: Oct 23, 2026

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery
Published on: May 19, 2018
Abstract:
Hepatocyte proliferation may be controlled by reversible patterns of endocrine changes, monitored by the liver, involving known hormones and their receptors. A two-programme model of related interactions among nutrients, specific lipoproteins, and highly phosphorylated nucleotides is postulated. This hypothesis stems from in vitro studies of rat hepatocyte proliferation under chemically defined conditions and from in vivo studies using partially hepatectomized, hormone-infused, developing and lipotrope-deficient rats. Certain findings are discussed with regard to receptor systems which show negatively cooperative properties; to problems of proliferative specificity; and to novel approaches for defined studies of chemical hepatocarcinogenesis.
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