[The support of postoperative renal function by ulinastatin in patients with preoperative renal dysfunction]

The principal perioperative management of patients with renal dysfunction is to prevent postoperative acute renal failure. Therefore, it is crucial to do all possible therapies by which its occurrence is prevented. We experienced three cases in which ulinastatin may have been beneficial to maintain postoperative renal function. The patients had preoperative renal dysfunction with serum Cr between 1.5 and 2.0 mg.dl-1. During the operation and for the three postoperative days, 300,000 units.day-1 of ulinastatin were administered intravenously. After the operation, serum Cr level was not elevated. Urine output and creatinine clearance increased. These three clinical cases suggest that ulinastatin may prevent the deterioration of postoperative renal function in patient with preoperative renal dysfunction.