Prophylactic therapy of Salmonella typhi septicemia in mice with a traditionally prescribed crude drug formulation

A crude drug formulation comprised of eight medicinal herb extracts was studied for in vitro and in vivo effect against Salmonella typhi. The formulation displayed inhibitory action against the test organism in vitro. Subsequently mice were challenged with a virulent strain of Salmonella typhi (Ty2) and the protective effect of the formulation was evaluated with post-infective, pre-infective, single and multiple dose schedules, administered either orally or subcutaneously. A schedule that included multiple divided doses prophylactically administered had a significant therapeutic effect.