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Transcutaneous drug delivery: a practical review
1Department of Internal Medicine, Mayo Clinic Rochester, Minnesota 55905, USA.
Mayo Clinic Proceedings
|June 1, 1995
Summary
Transdermal drug delivery offers a safe and effective alternative to oral medications, bypassing the digestive system for improved patient outcomes. This method enhances therapeutic options by controlling absorption and utilizing various skin sites.
Area of Science:
- Pharmacology
- Dermatology
- Drug Delivery Systems
Background:
- Transcutaneous drug delivery involves applying medications to the skin for systemic absorption.
- Factors influencing efficacy include drug properties, vehicle composition, penetration enhancers, and the delivery device.
Purpose of the Study:
- To outline the benefits and drawbacks of transcutaneous drug delivery.
- To discuss practical aspects and future advancements in this drug administration route.
Main Methods:
- Physiochemical properties of drug preparations were analyzed.
- The role of vehicles, penetration enhancers, and delivery systems in transdermal transport was examined.
Main Results:
- Advantages include bypassing gastrointestinal metabolism, controlled absorption, site versatility, and enhanced patient compliance.
- Disadvantages involve potential skin reactions, systemic toxicity, and diffusion time limitations.
Conclusions:
- Transdermal drug regimens are established as safe and effective therapeutic strategies.
- They expand treatment possibilities for optimizing patient care.