[Cytokines in immunopathogenesis of pulmonary tuberculosis]

Production of IL-1, IL-2, gamma-interferon and PNO was measured in 46 patients with various forms of pulmonary tuberculosis. Cytokins quantitation was conducted biologically, using radioimmunoassay and enzyme immunoassay in supernatants of cellular structures (blood lymphocytes). There were high levels of IL-1 and PNO, reduced production of IL-2 and gamma-IFN by stimulated blood mononuclears. In effective chemotherapy (3-4 months) production of IL-1 tented to a decline, while that of IL-2 and gamma-IFN went up.