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Teeth and tooth nerves

C Hildebrand1, K Fried, F Tuisku

  • 1Department of Cell Biology, University of Linköping, Sweden.

Progress in Neurobiology
|February 1, 1995
PubMed
Summary
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The evolution of teeth is linked to vertebrate exoskeletal armor and sensory functions. Nerve development is crucial for tooth formation and turnover, especially in non-mammalian vertebrates.

Area of Science:

  • Evolutionary biology
  • Developmental biology
  • Neuroscience

Background:

  • Tooth and nerve knowledge has advanced, but key questions remain.
  • Hard tissues like dentin and enamel evolved from vertebrate exoskeletal armor over 500 million years ago.
  • Early vertebrate armor may have had sensory functions, potentially preceding teeth.

Purpose of the Study:

  • To explore the evolutionary origins of teeth and their sensory functions.
  • To investigate the role of neural components in tooth development and turnover.
  • To understand the plasticity required for mammalian tooth replacement and dental changes.

Main Methods:

  • Comparative analysis of vertebrate dentition and evolutionary history.
  • Examination of neural involvement in tooth germ formation and turnover.

Related Experiment Videos

  • Histological and developmental studies of tooth primordia and innervation.

    • Main Results:

    • Teeth may have evolved from sensory tubercles in ancient bony armor.
    • Tooth turnover varies significantly between mammals and non-mammalian vertebrates.
    • Neural plasticity is essential for tooth turnover and adaptation to dental changes.
    • Denervation in teleosts disrupts tooth germ formation and halts turnover, unlike in mammals.

    Conclusions:

    • Tooth evolution is intertwined with sensory systems and vertebrate armor.
    • Neural regulation plays a critical role in tooth development and maintenance, particularly in non-mammals.
    • Further research promises breakthroughs in understanding teeth and their associated nerves.