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Updated: Aug 11, 2026

Real-time Digital Imaging of Leukocyte-endothelial Interaction in Ischemia-reperfusion Injury (IRI) of the Rat Cremaster Muscle
Published on: August 5, 2012
[C-reactive protein and biological defense]
1Kirurgisk avdeling B, Rikshospitalet, Oslo.
Abstract:
This article reviews recent findings suggesting a specific tumouricidal effect of C-reactive protein (CRP). A peptidic fragment of CRP, called RS 83277, has shown a significant anti-tumour effect in laboratory animals. The mechanism is not fully understood, but is possibly mediated via the macrophages. Both macrophages and monocytes show increased tumoricidal activity after stimulation with RS 83277. The article also reviews the regulation of CRP synthesis and secretion, as well as the structure, binding capacities, and important biological properties of CRP.
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