Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Criterion for inclusion in onchocerciasis control programmes based on ivermectin distribution

G De Sole

    Transactions of the Royal Society of Tropical Medicine and Hygiene
    |March 1, 1995
    PubMed
    Summary

    Ivermectin mass treatment criteria for onchocerciasis in West African savannas do not require modification. Current criteria, based on the risk of onchocercal blindness, are supported by findings on lymphatic and skin lesions in the studied communities.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Elimination of trachoma: follow up.

    The British journal of ophthalmology·1998
    Same author

    Elimination of trachoma.

    The British journal of ophthalmology·1997
    Same author

    Determining the importance of eye diseases in Africa.

    The British journal of ophthalmology·1996
    Same author

    Xerophthalmia in Rwandan refugees.

    The British journal of ophthalmology·1995
    Same author

    Distribution of onchocerciasis in selected river basins of four west African countries.

    Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)·1993
    Same author

    Distribution and severity of onchocerciasis in southern Benin, Ghana and Togo.

    Acta tropica·1992

    Area of Science:

    • Tropical medicine
    • Public health
    • Parasitology

    Background:

    • Onchocerciasis, a parasitic disease, causes lymphatic and skin lesions.
    • Mass treatment with ivermectin is a key intervention.
    • Current treatment guidelines are based on the risk of onchocercal blindness.

    Purpose of the Study:

    • To evaluate the existing criterion for ivermectin mass treatment inclusion.
    • To determine if the risk of onchocercal blindness criterion needs modification based on lesion data.

    Main Methods:

    • Analysis of lymphatic and skin lesion data from 45 West African savanna communities.
    • Examination of 10,108 individuals for onchocercal manifestations.
    • Stratification of lesion prevalence by age and community risk for blindness.

    Related Experiment Videos

    Main Results:

    • Only 16 cases of elephantiasis were reported in over 10,000 people.
    • Lymphatic and permanent skin lesions were more prevalent in older individuals (>30 years).
    • These lesions were significantly more common in villages identified as high-risk for onchocercal blindness.

    Conclusions:

    • The current criterion for ivermectin mass treatment, based on the risk of onchocercal blindness, remains appropriate for savanna areas.
    • No modification is needed for the inclusion criteria in West African savanna regions.
    • Lesion patterns observed support the continued use of blindness risk as the primary determinant for treatment eligibility.