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Inositol 1,4,5-trisphosphate receptors, secretory granules and secretion in endocrine and neuroendocrine cells
1Division of Molecular Medicine, Chiba University School of Medicine, Japan.
Trends in Neurosciences
|April 1, 1995
Abstract:
Recent studies have revealed the presence of inositol 1,4,5-trisphosphate receptors in the secretory granules of endocrine and neuroendocrine cells. This distribution suggests that inositol 1,4,5-trisphosphate-regulated release of granule stores of Ca2+ might facilitate the secretory process. In addition, inositol 1,4,5-trisphosphate receptors might participate directly in the biogenesis of secretory granules. The presence of inositol 1,4,5-trisphosphate receptors in synaptic nerve terminals raises the possibility that they might also be involved in the control of neurotransmitter release.