[Electroencephalographic markers and the computerized evaluation of the severity of depression]

In 24 patients with moderate, pronounced and extremely pronounced (according to Hamilton Scale) sings of depression EEG of frontal, temporal, parietal and occipital areas of brain hemispheres were investigated. Control group consisted of 24 normals, being under supervision for a year. 4 types of EEG patterns (matrices) probabilities of changes were selected; those parameters correlated with severity of depression and stage of depressive phase. A cyclic character of transformation of organization of bioelectric processes during the disease has been demonstrated: orders of matrices changes in cases with reduction and aggravation of depressive signs were opposite. Linear discriminant functions or EEG markers, significantly different for groups of patients with different severity of depression, have been obtained. It allowed to create the computer-based system of evaluation of depression severity with high diagnostic accuracy.