Related Experiment Videos
Bis(acetato)amminedichloro(cyclohexylamine)platinum(IV), an orally active anticancer drug
S Neidle1, C F Snook, B A Murrer
1CRC Biomolecular Structure Unit, Institute of Cancer Research, Sutton, Surrey, England.
Abstract:
The structure of the anticancer drug bis(acetato)-amminedichloro(cyclohexylamine)platinum(IV), [PtCl2-(C2H3O2)2(C6H13N)(NH3)], is reported. The acetato groups are axial to the square plane composed of the chlorine and amine substituents. The cyclohexane ring may sterically hinder one of the acetato groups for metabolic attack. The amine groups are hydrogen bonded to the carbonyl O atoms of the acetato groups.