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Epidemiological views into possible components of paediatric combined vaccines in 2015

J Eskola1

  • 1National Public Health Institute, Finland.

Biologicals : Journal of the International Association of Biological Standardization
|December 1, 1994
PubMed

Insights

Future childhood vaccines will combine existing immunizations with new antigens targeting encapsulated bacteria and respiratory viruses. This approach aims to prevent severe invasive infections, pneumonia, and congenital infections for broader public health protection.

Area of Science:

  • Pediatric Vaccinology
  • Infectious Disease Prevention
  • Public Health

Background:

  • Combined vaccines offer a streamlined approach to childhood immunization.
  • Existing vaccines have proven efficacy, forming the basis for new combinations.
  • Emerging infectious threats necessitate the development of broader-spectrum vaccines.

Purpose of the Study:

  • To outline the future development of combined vaccines for childhood immunization.
  • To identify key vaccine candidates for inclusion in next-generation combination vaccines.
  • To explore strategies for preventing bacterial, viral, and congenital infections through vaccination.

Main Methods:

  • Review of current vaccine development pipelines for encapsulated bacteria and respiratory viruses.
  • Analysis of the potential impact of novel antigens in combination vaccines.
  • Consideration of vaccines for congenital infections in adolescent immunization schedules.

Main Results:

  • Multivalent pneumococcal and meningococcal conjugate vaccines (groups A, B, C) are in clinical trials.
  • Pneumococcal conjugate vaccines are crucial for preventing respiratory infections.
  • Respiratory viruses (RSV, parainfluenza, adenoviruses) and pathogens causing congenital infections (HSV, CMV, GBS) are key targets.

Conclusions:

  • Combined vaccines will integrate existing and novel antigens for comprehensive disease prevention.
  • Vaccines against encapsulated bacteria and respiratory viruses are critical components.
  • Adolescent vaccination may include components to prevent congenital infections, protecting future offspring.

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