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Related Experiment Videos

Surgical patients with surprising laboratory data

E Leppänen1, M Luisto, B Dugué

  • 1Minerva Foundation Institute for Medical Research, Helsinki, Finland.

The British Journal of Clinical Practice
|May 1, 1995
PubMed
Summary
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Morning laboratory tests in orthopedic patients showed significantly lower levels of leukocytes, albumin, total protein, platelets, and total calcium. These preanalytical variations, influenced by posture and circadian rhythms, may impact surgical decisions.

Area of Science:

  • Clinical Biochemistry
  • Laboratory Medicine
  • Orthopedic Surgery

Background:

  • Preoperative laboratory testing is standard for elective surgeries.
  • Variations in patient physiology can affect test results.
  • Understanding preanalytical factors is crucial for accurate diagnostics.

Purpose of the Study:

  • To investigate diurnal variations in preoperative laboratory tests for ambulatory orthopedic patients.
  • To identify specific laboratory parameters affected by overnight changes.
  • To assess the clinical implications of these variations.

Main Methods:

  • Blood samples were collected from 26 elective ambulatory orthopedic patients.
  • Samples were taken on the afternoon of hospital arrival and the following morning before surgery.

Related Experiment Videos

  • Concentrations of leukocytes, albumin, total protein, platelets, and total calcium were measured.

    • Main Results:

    • Significantly lower concentrations of leukocytes, albumin, total protein, platelets, and total calcium were observed in morning samples compared to afternoon samples.
    • These diurnal variations suggest a potential influence of posture and circadian rhythms.
    • The observed changes highlight the impact of preanalytical factors on laboratory values.

    Conclusions:

    • Overnight changes in laboratory values can occur in preoperative patients.
    • These variations may lead to unnecessary investigations and surgical delays.
    • Clinicians must be aware of preanalytical factors, such as diurnal rhythms, affecting laboratory data.