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Microvessel quantitation in invasive breast cancer by staining for factor VIII-related antigen
1First Department of Surgery, Osaka City University Medical School, Japan.
Abstract:
The clinical importance of microvessel quantitation as a prognostic indicator in invasive breast cancer was examined. This study included 155 patients with invasive breast cancer, with a median follow-up of 82 months. Microvessels were identified by immunohistochemical staining for factor VIII-related antigen in formalin-fixed, paraffin-embedded primary tumours. For each tumour, microvessels were counted within a 200 x magnification field in the area of highest microvessel density. Microvessel counts (MVCs) had no correlation with tumour size, lymph node status or histological grade. When patients were classified by MVC, higher counts were associated with shorter disease-free survival and overall survival (P < 0.025 and P < 0.01 respectively). Multivariate analysis showed that MCV is an independent prognostic factor. Microvessel quantitation may be a useful predictor for identifying breast cancer patients at high risk for relapse and death.
Insights
Quantifying microvessel counts (MVCs) in invasive breast cancer can predict patient outcomes. Higher microvessel density indicates a greater risk of disease recurrence and mortality, aiding in risk stratification for breast cancer patients.
Area of Science:
- Oncology
- Pathology
- Medical Diagnostics
Background:
- Assessing prognostic indicators in invasive breast cancer is crucial for patient management.
- Microvessel density has been investigated as a potential prognostic marker.
Purpose of the Study:
- To evaluate the clinical significance of microvessel quantitation as a prognostic indicator in invasive breast cancer.
- To determine if microvessel counts correlate with established prognostic factors and patient survival.
Main Methods:
- Immunohistochemical staining for factor VIII-related antigen was used to identify microvessels.
- Microvessel counts (MVCs) were quantified in the area of highest density within primary breast tumors from 155 patients.
- Median follow-up was 82 months.
Main Results:
- Microvessel counts showed no correlation with tumor size, lymph node status, or histological grade.
- Higher MVCs were significantly associated with shorter disease-free survival (P < 0.025) and overall survival (P < 0.01).
- Multivariate analysis confirmed MVC as an independent prognostic factor.
Conclusions:
- Microvessel quantitation is a valuable prognostic tool in invasive breast cancer.
- Higher microvessel density predicts a poorer prognosis, identifying patients at high risk for relapse and death.
- This method may assist in tailoring treatment strategies for breast cancer patients.