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Pseudohomogeneous kinetic study on a two-liquid-phase fermentation process

Y Li1, Z Cao, N Yuan

  • 1Department of Chemical Engineering, Tsinghua University, Beijing, China.

Chinese Journal of Biotechnology
|January 1, 1994
PubMed
Summary
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This study optimized undecane dicarboxylic acid production from tridecane using a four-phase fermentation process. Cell growth was accurately identified by carbon dioxide production rate (CPR), enabling effective kinetic modeling for enhanced yields.

Area of Science:

  • Biochemical Engineering
  • Industrial Microbiology
  • Process Optimization

Background:

  • The production of dicarboxylic acids is crucial for various industrial applications.
  • Fermentation processes involving multiple phases present complex challenges in optimization.
  • Understanding metabolic characteristics is key to improving bioprocess efficiency.

Purpose of the Study:

  • To investigate and optimize the fermentation process for producing undecane dicarboxylic acid from tridecane.
  • To analyze the metabolic differences between the cell growth and production phases.
  • To develop kinetic models for both phases of the fermentation process.

Main Methods:

  • Studied a four-phase (gas-oil-water-cell, two-liquid-phase) fermentation system.

Related Experiment Videos

  • Analyzed metabolic characteristics during cell growth and production phases.
  • Established and validated kinetic models using regression analysis and experimental data.

    • Main Results:

    • Identified carbon dioxide production rate (CPR) as a reliable indicator for cell growth.
    • Developed distinct kinetic models for the cell growth and production phases.
    • Achieved high model accuracy with average deviations of 2.4% for cell growth and 3.6% for production.

    Conclusions:

    • The proposed method accurately predicts cell growth using CPR, facilitating process control.
    • The established kinetic models effectively describe the fermentation process, enabling optimization.
    • This research provides a foundation for improving the industrial production of undecane dicarboxylic acid.