Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Characteristics of multiple-shock defibrillation

R J Sweeney1, R M Gill, P R Reid

  • 1Department of Electrophysiology Research, Lilly Research Laboratory Division, Eli Lilly and Company, Indianapolis, Indiana, USA.

Journal of Cardiovascular Electrophysiology
|February 1, 1995
PubMed
Summary

A new defibrillation method uses timed shock sequences to reduce current requirements. Two- or three-shock sequences with equal amplitudes significantly lower defibrillation current, offering potential for low-current devices.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and metabolic effects associated with weight changes and obeticholic acid in non-alcoholic steatohepatitis.

Alimentary pharmacology & therapeutics·2018
Same author

Perilymph pharmacokinetics of locally-applied gentamicin in the guinea pig.

Hearing research·2016
Same author

Perilymph Kinetics of FITC-Dextran Reveals Homeostasis Dominated by the Cochlear Aqueduct and Cerebrospinal Fluid.

Journal of the Association for Research in Otolaryngology : JARO·2015
Same author

The auditory nerve overlapped waveform (ANOW) originates in the cochlear apex.

Journal of the Association for Research in Otolaryngology : JARO·2014
Same author

Adding liquid feed to a total mixed ration reduces feed sorting behavior and improves productivity of lactating dairy cows.

Journal of dairy science·2012
Same author

Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases.

Oncogene·2011

Area of Science:

  • Cardiovascular Research
  • Biomedical Engineering
  • Medical Devices

Background:

  • Current defibrillation methods rely on single high-energy shocks.
  • Optimizing defibrillation requires understanding shock parameters and timing.
  • A novel approach combines multiple shocks with adjusted separation for improved efficacy.

Purpose of the Study:

  • To investigate the characteristics of a new multi-shock defibrillation method.
  • To determine optimal parameters for reduced current defibrillation.
  • To assess the applicability of this method with biphasic waveforms and sequential pathways.

Main Methods:

  • Experiments were conducted on 48 pentobarbital-anesthetized dogs.
  • Sequences of rectangular shocks were used to determine 50% defibrillation success.

Related Experiment Videos

  • Parameters studied included shock duration, amplitude balance, waveform type, and shock pathway.

    • Main Results:

    • Two-shock sequences followed a strength-duration curve below that of single shocks.
    • Equal amplitude shocks in two-shock sequences yielded the best performance.
    • Combining this method with biphasic waveforms or sequential pathways resulted in additive current reduction.
    • A three-shock sequence required 33% less current than a single shock.

    Conclusions:

    • The new method allows defibrillation current to be distributed over multiple cycles.
    • Improved strength-duration relationships were observed.
    • Two- and three-shock sequences significantly reduce defibrillation current.
    • This approach is compatible with biphasic waveforms and sequential pathways, indicating potential for low-current defibrillation devices.