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Updated: Aug 19, 2026
Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines
Published on: September 3, 2016
Relationship of histology, DNA-values and proliferative activity in unselected breast cancer patients (a preliminary
A Niezabitowski1, J Ryś, B Lackowska
1Department of Tumor Pathology, Epidemiology and Surgery, Center of Oncology, Kraków.
Abstract:
Based upon a group of 108 consecutive mammary carcinomas a comparative analysis of morphological parameters, DNA-ploidy and indicators of proliferation activity was made. A correlation between Bloom-Richardson scale, mitotic index, PCNA-labeling index and DNA-index was shown. The ploidy of mammary carcinomas was significantly related to the values of proliferative fraction, as well as to PCNA-labeling index. Among patients with axillary metastases the tumor size and the value of PCNA-labeling index were significantly higher than those in patients with negative lymph nodes.
