Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac transplantation: a review

M Yeatman1, J A Smith, J J Dunning

  • 1Transplant Unit, Papworth Hospital, Cambridge, UK.

Cardiovascular Surgery (London, England)
|February 1, 1995
PubMed
Summary

Cardiac transplantation is a successful treatment for heart failure, but long-term success is limited by complications and donor organ shortages. Further research into immunosuppression and alternative therapies is crucial for improving patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Free radical generation in hydroperoxide-treated erythrocytes monitored continuously by luminol-amplified chemiluminescence.

Biochemistry international·1992
Same author

The presence of high-titer HLA antibodies in cardiac transplant recipients.

Transplantation·1992
Same author

Role of guinea pig and rabbit hepatic aldehyde oxidase in oxidative in vitro metabolism of cinchona antimalarials.

Drug metabolism and disposition: the biological fate of chemicals·1992
Same author

Comparison of intravenous contrast agents for CT studies in children.

Acta radiologica (Stockholm, Sweden : 1987)·1992
Same author

kappa-Opioid inhibition of [3H]dopamine release from rat ventral mesencephalic dissociated cell cultures.

Molecular pharmacology·1992
Same author

Mechanical circulatory support: a necessary adjunct to a cardiac transplantation service.

Transplantation proceedings·1992

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Immunology

Background:

  • Cardiac transplantation is a leading treatment for end-stage heart failure.
  • Long-term outcomes are compromised by coronary vasculopathy, infections, and malignancies.
  • The global supply of donor organs significantly restricts transplantation program activity.

Purpose of the Study:

  • To review the current state and limitations of cardiac transplantation.
  • To discuss strategies for improving long-term graft survival.
  • To explore the potential of alternative therapeutic options.

Main Methods:

  • Literature review of cardiac transplantation outcomes and challenges.
  • Analysis of factors limiting long-term graft survival.
  • Discussion of advancements in immunosuppressive therapy.
  • Evaluation of donor organ availability and strategies to expand the donor pool.

Main Results:

  • While successful, cardiac allografts face long-term complications like vasculopathy, infection, and cancer.
  • Immunosuppressive agent refinement may improve acute and chronic rejection prevention.
  • Donor organ availability remains a critical bottleneck, with limited prospects for significant expansion.
  • Alternative strategies to allograft transplantation require further investigation.

Conclusions:

  • Cardiac transplantation offers significant benefits but requires ongoing management of long-term complications.
  • Improvements in immunosuppression are vital for enhancing graft longevity.
  • Addressing the donor organ shortage necessitates exploring novel therapeutic approaches beyond traditional transplantation.

Related Experiment Videos