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[Oncogenic osteomalacic myopathy; a case report]

M Urushitani1, K Nishinaka, F Udaka

  • 1Department of Neurology, Sumitomo Hospital.

Rinsho Shinkeigaku = Clinical Neurology
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

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A patient with oncogenic osteomalacic myopathy experienced muscle weakness due to a rib tumor. Tumor removal resolved symptoms and normalized phosphorus levels, highlighting the link between mesenchymal tumors and osteomalacia.

Area of Science:

  • Endocrinology
  • Neurology
  • Oncology

Background:

  • Oncogenic osteomalacia is a rare paraneoplastic syndrome characterized by renal phosphate wasting.
  • It often presents with muscle weakness, bone pain, and biochemical abnormalities.

Observation:

  • A 54-year-old man presented with progressive muscle weakness and cramps, low serum phosphorus, and elevated alkaline phosphatase.
  • Electromyography showed myogenic changes, and muscle biopsy revealed myopathic alterations.
  • A primitive mesenchymal tumor of the 10th rib was identified.

Findings:

  • Surgical resection of the mesenchymal tumor led to immediate and significant relief of muscle symptoms.
  • Post-operatively, serum inorganic phosphorus, tubular reabsorption of phosphorus, and 1,25-dihydroxyvitamin D levels normalized.

Related Experiment Videos

  • Electromyography normalized, indicating resolution of the myopathy.

    • Implications:

    • This case underscores the importance of considering oncogenic osteomalacia in patients with unexplained myopathy and hypophosphatemia.
    • Mesenchymal tumors, even benign ones, can secrete phosphaturic substances causing profound metabolic bone disease.
    • Timely diagnosis and surgical management of the underlying tumor are crucial for successful treatment of oncogenic osteomalacia.