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Updated: Jul 19, 2026
07:54
Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Cardiac hypertrophy in obstructive sleep apnea syndrome
1Department of Clinical Laboratory Medicine, Nagoya University College of Medical Technology, Nagoya University Hospital, Japan.
Chest
|June 1, 1995
Summary
Obstructive sleep apnea syndrome (OSAS) is linked to heart problems. Frequent oxygen drops and arousal responses in OSAS patients may cause long-term left and right ventricular hypertrophy (LVH/RVH).
Area of Science:
- Cardiology
- Sleep Medicine
- Pulmonology
Background:
- Obstructive sleep apnea syndrome (OSAS) is a common condition characterized by repeated episodes of airway obstruction during sleep.
- OSAS is associated with cardiovascular complications, including hypertension and cardiac remodeling.
- The specific mechanisms linking OSAS to ventricular hypertrophy require further elucidation.
Purpose of the Study:
- To investigate the prevalence of left ventricular hypertrophy (LVH) and right ventricular hypertrophy (RVH) in middle-aged male patients with OSAS.
- To explore the relationship between OSAS severity, nocturnal oxygen desaturation, and the development of LVH and RVH.
- To assess the role of sympathetic activity, measured by plasma norepinephrine (NE), in the pathophysiology of OSAS-related cardiac changes.
Main Methods:
- Fifty-one middle-aged male patients with OSAS underwent comprehensive evaluation.
- Methods included two-dimensional echocardiography, 24-hour ambulatory blood pressure monitoring, polysomnography, and plasma norepinephrine measurements.
- Patients were categorized based on apnea index to compare cardiac parameters and OSAS severity.
Main Results:
- Left ventricular hypertrophy (LVH) was observed in 41.2% and right ventricular hypertrophy (RVH) in 11.8% of patients.
- Higher apnea index and prolonged duration of nocturnal oxygen saturation <90% were significantly correlated with LVH, RVH, increased LV mass, and elevated 24-hour mean blood pressure.
- Plasma norepinephrine levels increased significantly after waking and correlated with the duration of oxygen desaturation.
Conclusions:
- Frequent oxygen desaturation and arousal episodes in OSAS may contribute to the long-term development of LVH and RVH.
- Apnea-induced cyclical blood pressure surges and sustained hypertension, coupled with increased afterload and sympathetic activity, likely play a role in LVH development.
- These findings underscore the importance of managing OSAS to prevent cardiovascular complications.
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