Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interaction between nifedipine and digoxin in rats

C K Maitai1, D K Njoroge, R W Munenge

  • 1Department of Pharmacy, College of Health Sciences University of Nairobi, Kenya.

East African Medical Journal
|January 1, 1995
PubMed
Summary

Nifedipine significantly lowers the lethal dose of digoxin in rats, suggesting a dangerous drug interaction. This study highlights potential risks of combining nifedipine and digoxin in patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacokinetics of phenytoin following intravenous and intramuscular administration of fosphenytoin and phenytoin sodium in the rabbit.

European journal of drug metabolism and pharmacokinetics·2002
Same author

Pharmacological properties of extracts from the stem bark of Syzygium guineense on the ileum and heart of laboratory rodents.

African journal of health sciences·1997
Same author

Evaluation of tetracycline raw materials and finished products found on the Kenyan market.

Journal of pharmaceutical and biomedical analysis·1994
Same author

Drug quality control work in Daru: observations during 1983-1986.

East African medical journal·1992
Same author

A comparison of organochlorine pesticide residues in maternal adipose tissue, maternal blood, cord blood, and human milk from mother/infant pairs.

Archives of environmental contamination and toxicology·1992
Same author

Khat-induced paranoid psychosis.

The British journal of psychiatry : the journal of mental science·1988

Area of Science:

  • Pharmacology
  • Toxicology
  • Cardiovascular Research

Background:

  • Nifedipine and digoxin are commonly prescribed cardiovascular drugs.
  • Potential drug interactions between nifedipine and digoxin require investigation to ensure patient safety.

Purpose of the Study:

  • To investigate the potential interaction between nifedipine and digoxin.
  • To determine if nifedipine affects the lethal dose of digoxin in a rat model.

Main Methods:

  • Lethal doses of digoxin were compared in control and nifedipine-pretreated rats.
  • Nifedipine was administered intraperitoneally 30 minutes before intravenous digoxin infusion.
  • Digoxin was infused at a constant rate of 40 mcg/minute.

Main Results:

  • Nifedipine reduced the lethal dose of digoxin by 26-38% in experimental rats.
  • The interaction showed minimal dose dependence within the tested nifedipine dosage range (0.5-2.0 mg/kg).
  • A synergistic effect between nifedipine and digoxin was indicated.

Conclusions:

  • Concomitant administration of nifedipine and digoxin may lead to significant drug interactions in humans.
  • Clinicians should exercise caution when prescribing these drugs together.
  • Further studies are warranted to elucidate the mechanisms of this interaction.

Related Experiment Videos