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Pancreatic disorders of pregnancy. Pregestational diabetes
K Healy1, L Jovanovic-Peterson, C M Peterson
1Sansum Medical Research Foundation, Santa Barbara, California, USA.
The outcome of pregnancies complicated by pregestational diabetes, both insulin-dependent and non-insulin-dependent, has changed dramatically since the discovery of insulin in the early 1920s. Now, patients with pregestational diabetes can safely undergo a pregnancy and be assured that the infant will be healthy. Unfortunately, a finite risk of problems still may occur, including congenital malformations, spontaneous abortions, and diabetic fetopathy classically manifest as a macrosomic infant. Treatment strategies, although tedious and sometimes onerous, do minimize these risks.
The outcome of pregnancies complicated by pregestational diabetes, both insulin-dependent and non-insulin-dependent, has changed dramatically since the discovery of insulin in the early 1920s. Now, patients with pregestational diabetes can safely undergo a pregnancy and be assured that the infant will be healthy. Unfortunately, a finite risk of problems still may occur, including congenital malformations, spontaneous abortions, and diabetic fetopathy classically manifest as a macrosomic infant. Treatment strategies, although tedious and sometimes onerous, do minimize these risks.