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Related Experiment Videos

Is bladder conservation feasible? An Indian experience

A V Dalal1, H B Tongaonkar, N Dandekar

  • 1Department of Urooncology, Tata Memorial Hospital, Parel, Bombay, India.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

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Neoadjuvant chemotherapy with MVAC regimens shows promise for muscle invasive bladder cancer, enabling bladder preservation in over half of patients. This approach may identify patients with a favorable prognosis for organ conservation.

Area of Science:

  • Oncology
  • Urology

Background:

  • Chemotherapy, including MVAC (methotrexate, vinblastine, adriamycin, cisplatin), is used for muscle invasive bladder cancer.
  • High response rates with MVAC/CMV regimens support organ conservation efforts.

Purpose of the Study:

  • To evaluate the efficacy of MVAC chemotherapy for muscle invasive bladder cancer.
  • To assess the feasibility of bladder preservation following initial chemotherapy.

Main Methods:

  • A phase II study using neoadjuvant MVAC chemotherapy.
  • Bladder preservation was attempted based on response after two cycles, often with radiation therapy.
  • Median follow-up was 24 months for 29 patients.

Main Results:

  • Complete response (CR) in 24.1%, partial response (PR) in 38%, and no response (NR) in 38%.

Related Experiment Videos

  • Bladder conservation was achieved in 51.7% of patients, with 10 alive with bladders intact.
  • 100% of CR and 45% of PR patients could conserve their bladders; radical cystectomy was performed for non-responders.

    • Conclusions:

    • Initial MVAC chemotherapy may select patients with a good prognosis for bladder conservation.
    • Lower stage and grade tumors showed a higher likelihood of bladder preservation.
    • While preliminary, the findings suggest a role for neoadjuvant chemotherapy in bladder preservation strategies.