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Accelerated hybridization of oligonucleotides to duplex DNA

M Iyer1, J C Norton, D R Corey

  • 1Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas 75235, USA.

Summary

Two strategies accelerate DNA hybridization using modified oligonucleotides and peptide nucleic acid oligomers. These chemical modifications significantly enhance strand association for applications in DNA polymerization and gene expression.

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