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Managing medication in the elderly

A J Piraino1

  • 1Department of Medicine, Medical College of Pennsylvania, Philadelphia, USA.

Hospital Practice (1995)
|June 15, 1995
PubMed
Summary
This summary is machine-generated.

Elderly individuals consume a significant portion of medications, facing unique risks beyond age-related physiological changes. Prescribing for seniors requires careful consideration of drug properties and variations, such as anticholinergic effects and generic drug differences.

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Area of Science:

  • Geriatric Pharmacology
  • Drug Safety in the Elderly

Background:

  • Older adults account for a substantial percentage of prescription (30%) and over-the-counter (40%) drug use.
  • Age-related physiological changes can alter drug bioavailability and clearance, complicating medication management.

Purpose of the Study:

  • To highlight less recognized prescribing hazards for the elderly population.
  • To emphasize the importance of considering drug-specific properties and formulation differences in geriatric pharmacotherapy.

Main Methods:

  • Review of existing literature on geriatric pharmacotherapy and drug-related adverse events.
  • Analysis of drug properties, focusing on anticholinergic effects and generic drug variations.

Main Results:

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  • Anticholinergic properties of many drugs pose significant risks to the elderly.
  • Marked differences can exist between brand-name drugs and their generic counterparts, impacting efficacy and safety.

    • Conclusions:

    • Prescribing for the elderly necessitates a thorough understanding of drug mechanisms and potential variations.
    • Awareness of anticholinergic burden and generic equivalency is crucial for optimizing geriatric medication safety.