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In-vitro fertilization in completely natural cycles
U M Fahy1, D J Cahill, P G Wardle
1Department of Obstetrics and Gynaecology, University of Bristol, St Michael's Hospital, UK.
Human Reproduction (Oxford, England)
|March 1, 1995
Summary
Natural cycle in-vitro fertilization (IVF) shows promise for couples with tubal or unexplained infertility. This study found acceptable pregnancy rates, highlighting IVF
Area of Science:
- Reproductive Medicine
- Infertility Research
Background:
- Tubal disease and unexplained infertility are common causes of couple infertility.
- Natural cycle in-vitro fertilization (IVF) offers a less invasive approach compared to stimulated cycles.
Purpose of the Study:
- To evaluate the effectiveness of IVF in natural ovarian cycles for couples with tubal or unexplained infertility.
- To assess fertilization, implantation, and pregnancy rates in this specific patient population.
Main Methods:
- Prospective study involving 39 couples with tubal (n=26) or unexplained (n=13) infertility.
- Daily monitoring via blood sampling and vaginal ultrasonography, with oocyte retrieval at mid-cycle.
- 79 natural cycle IVF procedures were performed.
Main Results:
- Overall fertilization rate was 80% and implantation rate was 14.0%.
- A trend towards higher success rates was observed in women with tubal disease compared to unexplained infertility.
- No significant differences were noted between groups except for parity.
Conclusions:
- Natural cycle IVF provides a viable option for achieving pregnancy in couples with tubal and unexplained infertility.
- This method allows for detailed investigation of ovarian and follicular function.
- Further research is recommended to explore the lower success rates in unexplained infertility cases, focusing on follicular function and endocrinology.