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Two-generation reproduction toxicity study with isopropanol in rats
C Bevan1, T R Tyler, T H Gardiner
1Exxon Biomedical Sciences, Inc., East Millstone, NJ 08875, USA.
Journal of Applied Toxicology : JAT
|March 1, 1995
Summary
Isopropanol exposure in rats caused increased mortality and reduced body weight in offspring. Parental rats showed liver and kidney changes, but offspring had no other toxicity signs.
Area of Science:
- Toxicology
- Reproductive Toxicology
- Animal Studies
Background:
- Isopropanol is a common solvent with potential health effects.
- Understanding its reproductive toxicity is crucial for risk assessment.
Purpose of the Study:
- To evaluate the reproductive and developmental toxicity of isopropanol in rats across two generations.
Main Methods:
- A two-generation study design involving oral gavage administration of isopropanol (0, 100, 500, 1000 mg/kg) to rats.
- Dosing occurred before mating, during gestation, and lactation for parental (P1) and offspring (P2) generations.
Main Results:
- Parental rats exhibited increased liver and kidney weights, and hepatocyte hypertrophy. Kidney changes were observed in P1 and P2 males.
- High-dose F1 offspring experienced increased mortality and reduced body weight. F2 pups also showed reduced body weight.
- No other clinical signs of toxicity were noted in offspring, and no treatment-related post-mortem findings were observed.
Conclusions:
- Isopropanol exposure can lead to adverse effects on reproduction and development in rats, particularly impacting offspring survival and growth.
- Kidney and liver effects were observed in parental animals, suggesting target organ toxicity.
- Further investigation may be warranted to fully elucidate the mechanisms of isopropanol's reproductive toxicity.
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