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Related Experiment Videos

A persistent biochemical marker for partially treated meningitis/ventriculitis

R Katnik1

  • 1Michigan State University, Department of Pediatrics/Human Development, Kalamazoo 49008, USA.

Journal of Child Neurology
|March 1, 1995
PubMed
Summary

Cerebrospinal fluid ferritin levels can help diagnose central nervous system infections, especially when other markers are unclear. Elevated ferritin indicates infection, persisting even during antibiotic treatment.

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Myoadenylate deaminase deficiency.

Muscle & nerveยท1979
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Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Biochemistry

Background:

  • Iron regulation is crucial for managing bacterial, yeast, and fungal infections.
  • Ferritin, an iron-binding protein, plays a role in iron homeostasis.

Purpose of the Study:

  • To evaluate cerebrospinal fluid (CSF) ferritin levels in patients with central nervous system (CNS) infections.
  • To determine the diagnostic utility of CSF ferritin compared to traditional markers.

Main Methods:

  • CSF ferritin levels were measured in controls and patients with various CNS infections.
  • CSF ferritin concentrations were compared with CSF culture results, neutrophil counts, protein levels, and serum ferritin.

Main Results:

  • Elevated CSF ferritin (>18 ng/mL) was observed in culture-proven meningitis and ventriculitis.

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  • CSF ferritin levels were higher in infectious cases than controls, including some nonhemorrhagic aseptic meningitis cases.
  • Ferritin levels remained elevated during antibiotic treatment, suggesting its utility when traditional markers normalize or are ambiguous.

    • Conclusions:

    • CSF ferritin is a valuable biomarker for diagnosing CNS infections, particularly bacterial meningitis and ventriculitis.
    • Elevated CSF ferritin can persist during treatment, aiding diagnosis when conventional tests are inconclusive.
    • CSF ferritin levels do not correlate with CSF neutrophil count, protein, serum ferritin, or patient age.