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Related Experiment Videos

Hair

F J Ebling

    The Journal of Investigative Dermatology
    |July 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Hair growth cycles are controlled by hormones and innate programming. Androgenic hormones, like testosterone, influence sexual hair and male-pattern baldness by converting to active metabolites in the skin.

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    Area of Science:

    • Dermatology
    • Endocrinology
    • Hair Biology

    Background:

    • Human hair follicles exhibit intermittent activity, with most being vestigial except for scalp and sexual hair.
    • Key unresolved issues include control of hair follicle cycling, the influence of male hormones on the hair cycle, and the paradoxical effect of testosterone on scalp hair regression versus sexual hair growth.

    Purpose of the Study:

    • To investigate the factors controlling hair follicle activity and the role of hormones in hair growth cycles.
    • To explore the mechanisms behind androgenic hormone influence on sexual hair and male-pattern baldness.

    Main Methods:

    • Studies involved exchanging skin grafts from rats of different ages to assess innate programming and systemic influences.
    • Hormonal effects were examined, including the impact of steroid hormones (estrogens) and thyroid hormones on the hair cycle.

    Related Experiment Videos

  • Experiments explored the effects of epilation (hair plucking) at different stages of the hair cycle on subsequent follicle activity.
  • Metabolites of testosterone were analyzed in skin and hair roots, and their effects on sebaceous glands were studied in animal models.

    • Main Results:

    • Hair follicles possess innate programming but are susceptible to slow modification by systemic factors.
    • Estrogens decelerate the hair cycle (moult), while thyroid hormones accelerate it.
    • Epilation during the anagen (growth) phase did not prolong it, but surprisingly shortened the subsequent telogen (resting) phase.
    • Androgenic hormones, particularly 5alpha-dihydrotestosterone and androstenedione, are crucial for sexual hair growth and male-pattern baldness, with specific enzymes and binding proteins playing significant roles.

    Conclusions:

    • Hair growth is a complex process influenced by both intrinsic follicular programming and extrinsic hormonal factors.
    • Androgenic steroids and their metabolic pathways are key determinants of sexual hair characteristics and the development of male-pattern baldness.