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Platelet function studies in Indian kala-azar

B Dube1, A Arora, V P Singh

  • 1Department of Medicine, Banaras Hindu University, Varanasi, India.

The Journal of Tropical Medicine and Hygiene
|June 1, 1995
PubMed
Summary
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Indian kala-azar significantly impairs platelet function, causing thrombocytopenia and reduced platelet adhesiveness and aggregation. These platelet abnormalities correlate with impaired platelet factor III availability in patients.

Area of Science:

  • Hematology
  • Parasitology
  • Immunology

Background:

  • Kala-azar, a parasitic disease, can affect various bodily systems.
  • Platelet dysfunction is a potential complication of visceral leishmaniasis.

Purpose of the Study:

  • To investigate platelet function in Indian kala-azar patients.
  • To compare platelet parameters between kala-azar patients and healthy controls.

Main Methods:

  • Platelet function tests including platelet count, adhesive index, aggregation, and factor III availability were performed.
  • 25 parasitologically confirmed Indian kala-azar patients and 25 healthy controls were studied.

Main Results:

  • 92% of kala-azar patients exhibited thrombocytopenia, with 44% having platelet counts below 60,000/mm³.

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  • Reduced platelet adhesiveness (<30%) was observed in 70% of patients, and aggregation was prolonged.
  • Poor platelet factor III availability occurred in 40% of cases, correlating with reduced platelet adhesiveness.

    • Conclusions:

    • Indian kala-azar is associated with significant platelet function abnormalities.
    • Thrombocytopenia and impaired platelet adhesion/aggregation are common in kala-azar.
    • Platelet dysfunction may contribute to the pathophysiology of kala-azar.