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[Antimicrobial activities of piperacillin against fresh clinically isolated strains]
Abstract:
In order to evaluate the antimicrobial activity of piperacillin (PIPC), along with control agents, minimum inhibitory concentrations (MIC's) were determined against fresh clinically isolated strains from January to June, 1994. 1. The MIC70's of PIPC against major strains were approximately equal to those reported in the mid 1980s. 2. Strains for the study were supplied in approximately equal numbers from community-acquired hospitals and general hospitals. The ratios of bacteria resistant to beta-lactams including PIPC were low in the former group and high in the latter. 3. "New types of beta-lactam-resistant strains" which did not exist in mid 1980s but found at this time included benzylpenicillin (PCG)-insensitive Streptococcus pneumoniae, PCG-resistant S. pneumoniae, cephems-resistant Escherichia coli and beta-lactamase producing Prevotella spp. These bacteria were also found among strains obtained from community-acquired hospitals.
Insights
Antimicrobial activity of piperacillin (PIPC) remained stable, but resistance to beta-lactams is increasing in hospitals. New resistant bacterial strains, including Streptococcus pneumoniae and Escherichia coli, have emerged.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Context:
- Evaluation of antimicrobial activity of piperacillin (PIPC) against clinically isolated bacterial strains.
- Comparison of piperacillin's efficacy in mid-1980s versus 1994.
- Analysis of bacterial resistance patterns in community-acquired versus general hospitals.
Purpose:
- To determine the minimum inhibitory concentrations (MICs) of piperacillin and control agents.
- To identify emerging beta-lactam-resistant bacterial strains.
- To assess the prevalence of resistance in different hospital settings.
Summary:
- Piperacillin's MIC70 values against major strains showed stability compared to the mid-1980s.
- Bacterial resistance to beta-lactams, including piperacillin, was higher in general hospitals than in community-acquired hospitals.
- New beta-lactam-resistant strains, such as benzylpenicillin-insensitive Streptococcus pneumoniae and beta-lactamase-producing Prevotella spp., were identified.
Impact:
- Highlights the need for ongoing surveillance of antimicrobial resistance.
- Informs clinical decisions regarding antibiotic use and treatment strategies.
- Identifies specific bacterial strains and resistance mechanisms requiring further investigation.