Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glomerular morphometry in childhood reflux nephropathy, emphasizing the capillary changes

K Akaoka1, R H White, F Raafat

  • 1Department of Nephrology, Children's Hospital, Birmingham, United Kingdom.

Kidney International
|April 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bermudagrass Dead Spot: A New Disease of Bermudagrass Caused by Ophiosphaerella agrostis.

Plant disease·2019
Same author

Impact of coal-carrying trains on particulate matter concentrations in South Delta, British Columbia, Canada.

Environmental pollution (Barking, Essex : 1987)·2017
Same author

Predictors of post-thrombotic syndrome in a population with a first deep vein thrombosis and no primary venous insufficiency.

Journal of thrombosis and haemostasis : JTH·2013
Same author

Risk of post-thrombotic syndrome after subtherapeutic warfarin anticoagulation for a first unprovoked deep vein thrombosis: results from the REVERSE study.

Journal of thrombosis and haemostasis : JTH·2012
Same author

Comparison of the Villalta post-thrombotic syndrome score in the ipsilateral vs. contralateral leg after a first unprovoked deep vein thrombosis.

Journal of thrombosis and haemostasis : JTH·2012
Same author

The biosynthesis of n-[(2)H (7)] fatty acids byArthrobacter globiformis from [U-(2)H (15)] octanoic acid.

Lipids·2011
Same journal

Beyond galactose deficiency: redefining pathogenic IgA in IgA nephropathy.

Kidney international·2026
Same journal

KDIGO Life Cycle of Guideline Development Series Part 6: Bridging the Gap between Guidelines and Clinical Practice: The KDIGO Approach to Global Implementation and Education in Nephrology.

Kidney international·2026
Same journal

KDIGO Life Cycle of Guideline Development Series Part 5: Guideline updates and a living model for the future.

Kidney international·2026
Same journal

Crystal-storing histiocytosis causing severe acute kidney injury.

Kidney international·2026
Same journal

Peritoneal dialysis in a patient with extensive burn scarring.

Kidney international·2026
Same journal

COPA syndrome unmasked by anti-neutrophil cytoplasmic antibody-positive immune-complex nephritis.

Kidney international·2026
See all related articles

Reflux nephropathy causes significant glomerular hypertrophy in children. This study found that increased glomerular size is mainly due to capillary growth, not dilation, resembling normal growth patterns.

Area of Science:

  • Pediatric Nephrology
  • Renal Pathology
  • Glomerular Biology

Background:

  • Reflux nephropathy (RN) leads to significant glomerular hypertrophy due to nephron loss.
  • Understanding the mechanisms of this hypertrophy is crucial for pediatric kidney disease management.

Purpose of the Study:

  • To differentiate between capillary dilatation and capillary growth as causes of glomerular hypertrophy in children with RN.
  • To compare glomerular growth patterns in RN with those in healthy children.

Main Methods:

  • Computerized digitometry was used to measure glomerular tuft area (GTA), capillary luminal area (CLA), and number of lumens (N) in renal biopsies.
  • Mesangial area (MA) was calculated, and mesangial cell counts were performed.
  • Patients with RN were compared to controls with minimal change nephrotic syndrome and recurrent hematuria.

Related Experiment Videos

Main Results:

  • Glomerular tuft area (GTA), number of lumens (N), and mesangial area (MA) were significantly larger in children with RN compared to controls.
  • Capillary luminal area (CLA) and fractional mesangial area did not differ between groups.
  • The number of lumens (N) strongly correlated with glomerular tuft area (GTA4) in both RN and control groups.

Conclusions:

  • Capillary growth by subdivision, rather than dilatation, is the primary driver of glomerular hypertrophy in childhood reflux nephropathy.
  • The compensatory glomerular growth in RN appears to follow the normal growth pattern observed in healthy children.