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Increased density of cortical apolipoprotein E immunoreactive neurons in rabbit brain after dietary administration of
1Sanders-Brown Center on Aging, University of Kentucky Medical Center, Lexington 40536-0230, USA.
Neuroscience Letters
|March 3, 1995
Abstract:
Rabbits were fed 2% cholesterol diet for 4, 6 and 8 weeks or control diet for 6 weeks. Frontal cortex and hippocampal formation were stained with apolipoprotein E (Apo-E) antibody using standard immunocytochemical methods. The number of neurons expressing the Apo-E epitope and the intensity of Apo-E immunoreactivity increased with increasing time on the cholesterol diet. Because Apo-E chaperones cholesterol in the brain, the data may suggest that elevated circulating levels of cholesterol eventually cause increased cerebral levels.