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Related Experiment Videos

Dirithromycin increases ethinyl estradiol clearance without allowing ovulation

D P Wermeling1, M H Chandler, G D Sides

  • 1Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington, USA.

Obstetrics and Gynecology
|July 1, 1995
PubMed
Summary
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Dirithromycin slightly increased ethinyl estradiol clearance but did not affect oral contraceptive effectiveness or cause ovulation in healthy women. The drug interaction appears clinically insignificant.

Area of Science:

  • Pharmacology
  • Endocrinology
  • Drug Interactions

Background:

  • Oral contraceptives (OCs) containing ethinyl estradiol (E2) are widely used.
  • Potential drug interactions can compromise OC effectiveness.
  • Dirithromycin is an antibiotic with a potential for drug interactions.

Purpose of the Study:

  • To investigate a potential drug interaction between oral contraceptives and dirithromycin.
  • To assess the impact of dirithromycin on ethinyl estradiol (E2) pharmacokinetics.
  • To evaluate the effect on oral contraceptive effectiveness and ovulation.

Main Methods:

  • A nonblinded study involving 20 women using Ortho Novum 7/7/7-28.
  • Pharmacokinetic analysis of ethinyl estradiol (E2) and serum hormone levels.

Related Experiment Videos

  • Pelvic ultrasounds were used to monitor for ovulation.
  • Dirithromycin was administered for 14 days during cycle two.

    • Main Results:

    • A statistically significant 7.6% decrease in the 24-hour area under the curve for ethinyl estradiol (E2) was observed.
    • Apparent oral clearance of E2 increased following dirithromycin administration.
    • No instances of ovulation were detected in any participant.

    Conclusions:

    • Dirithromycin administration leads to increased apparent oral clearance of ethinyl estradiol (E2).
    • The clinical significance of this interaction is likely negligible.
    • No compromise in oral contraceptive effectiveness was observed in this study population.