Related Experiment Videos
[Growth hormone therapy in adults]
1Haynal Imre Egészségtudományi Egyetem, Budapest, I. Belgyógyászati Klinika.
Orvosi Hetilap
|June 4, 1995
Summary
Growth hormone (GH) deficiency in adults leads to poor body composition. GH therapy can reverse these changes, improving lean mass and reducing fat, particularly in elderly patients with catabolic conditions.
Area of Science:
- Endocrinology
- Gerontology
- Metabolism
Context:
- Adult growth hormone (GH) deficiency is linked to reduced lean body mass and increased adiposity.
- Aging involves similar body composition changes, potentially due to diminished GH secretion.
- Human GH (hGH) replacement therapy can partially reverse these age-related changes.
Purpose:
- To explore the role of diminished GH secretion in geriatric body composition changes.
- To evaluate the effects of GH treatment in GH-deficient adults and elderly individuals.
Summary:
- GH treatment in GH-deficient adults increases nitrogen retention and lean body mass while decreasing body fat percentage.
- Clinical studies demonstrate beneficial effects of hGH in protein catabolic disorders.
- Low-dose regimens minimize short-term adverse effects of GH therapy.
Impact:
- GH therapy is beneficial for specific elderly patients, including those with catabolic illnesses, malnutrition, burns, or cachexia.
- Consideration of GH treatment is warranted for GH-deficient adults.
- Understanding GH's role in aging may lead to improved therapeutic strategies for age-related body composition decline.