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[19F-MR imaging of transplanted tumor: perfluorochemicals as a fluorine tumor imaging agent]
Y H Itoh1, Y Kandori, M Takahashi
1Department of Radiology, Aichi Medical University.
Purpose:
The purpose of our study was to detect tumor selectively using 19F-magnetic resonance imaging (MRI) and to assess Fluosol-DA, a perfluorochemical emulsion, as a tumor imaging agent for 19F-MRI.
Materials And Methods:
SCC VII cells were transplanted in the right leg of mice. After 6 days, Fluosol-DA was administrated intravenously (40 ml/kg). 19F-MR imaging was performed on a Bruker CSI Omega 2 at 4.7 Tesla using a homemade volume coil.
Results:
In vitro, the concentration and 19F signal intensity of FDA showed a very high correlation (r = 0.9997). Detection on MRI was possible at a concentration of 2%. In vivo, images of 19F in SCC VII tumors were achieved in animals 2 days after the administration of FDA.
Conclusion:
Our study confirms the feasibility of 19F-MR in vivo imaging of tumors using the fluorine compound FDA.