Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fatty acids and adipose cell differentiation

G Ailhaud1, E Z Amri, P A Grimaldi

  • 1Centre de Biochimie (UMR 134 CNRS), Université de Nice-Sophia Antipolis, Faculté des Sciences, France.

Prostaglandins, Leukotrienes, and Essential Fatty Acids
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Latent TGFβ-binding proteins regulate UCP1 expression and function via TGFβ2.

Molecular metabolism·2021
Same author

Oxytocin and bone status in men: analysis of the MINOS cohort.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2015
Same author

Is obesity an adaptative response to inflammation?

Obesity reviews : an official journal of the International Association for the Study of Obesity·2012
Same author

PPARbeta activation induces rapid changes of both AMPK subunit expression and AMPK activation in mouse skeletal muscle.

Molecular endocrinology (Baltimore, Md.)·2011
Same author

Peroxisome proliferator-activated receptor beta activation promotes myonuclear accretion in skeletal muscle of adult and aged mice.

Pflugers Archiv : European journal of physiology·2009
Same author

Omega-6 fatty acids and excessive adipose tissue development.

World review of nutrition and dietetics·2008

Fatty acids are crucial for adipose tissue metabolism and cell differentiation. Research reveals a novel fatty acid-activated receptor that mediates these effects at the transcriptional level, highlighting fatty acids as signaling molecules.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Fatty acids are essential metabolic substrates for adipose tissue.
  • In preadipose cells, fatty acids regulate genes involved in their own metabolism.
  • Fatty acids also promote the differentiation of preadipose cells into mature adipose cells.

Purpose of the Study:

  • To investigate the molecular mechanisms by which fatty acids influence adipose tissue.
  • To identify the receptor mediating the transcriptional effects of fatty acids in adipose cells.
  • To elucidate the role of fatty acids as signaling molecules in adipocyte differentiation.

Main Methods:

  • cDNA cloning from a mouse Ob1771 preadipose cell library.
  • Identification and characterization of a novel receptor member of the steroid/thyroid hormone receptor superfamily.

Related Experiment Videos

Main Results:

  • Fatty acids act as potent inducers of genes related to fatty acid metabolism in preadipose cells.
  • Fatty acids induce terminal differentiation of preadipose cells into adipose cells.
  • A novel receptor, likely activated by fatty acids, was identified and implicated in transcriptional regulation.

Conclusions:

  • Fatty acids play a significant role in regulating gene expression and cell differentiation in adipose tissue.
  • The identified receptor is proposed to be the key mediator of fatty acid signaling in adipocytes.
  • Fatty acids function as novel signal transducing molecules involved in adipose cell differentiation.