Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fatty acids in cell signalling: modulation by lipid binding proteins

J F Glatz1, T Börchers, F Spener

  • 1Department of Physiology, University of Limburg, Maastricht, The Netherlands.

Prostaglandins, Leukotrienes, and Essential Fatty Acids
|February 1, 1995
PubMed
Summary

Long-chain fatty acids act as cell messengers. Specific lipid-binding proteins, like fatty acid-binding protein (FABP), facilitate their transport and influence fatty acid signaling pathways.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunohistochemical detection of very recent myocardial infarctions in humans with antibodies against heart-type fatty acid-binding protein.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Introduction to 'electrical propagation in smooth muscle organs'.

Acta physiologica (Oxford, England)·2014
Same author

Biosynthesis of cyclopentenylglycine from α-ketopimelate in Idesia polycarpa callus cultures.

Plant cell reports·2013
Same author

Characterization of two acyl-acyl carrier protein thioesterases from developing Cuphea seeds specific for medium-chain- and oleoyl-acyl carrier protein.

Planta·2013
Same author

Simultaneous mixture analysis using a dynamic microbial sensor combined with chemometrics.

Analytical chemistry·2011
Same author

Impaired cardiac functional reserve in type 2 diabetic db/db mice is associated with metabolic, but not structural, remodelling.

Acta physiologica (Oxford, England)·2010

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Signaling

Background:

  • Long-chain fatty acids and metabolites function as critical cell signaling molecules.
  • Their low aqueous solubility necessitates specific transport mechanisms.
  • Cytoplasmic fatty acid-binding proteins (FABPs) are key facilitators of intracellular lipid transport.

Purpose of the Study:

  • To survey the biological significance of intracellular lipid-binding proteins.
  • To explore the modulatory roles of FABPs in fatty acid-mediated signal transduction.
  • To understand the transport mechanisms of hydrophobic signaling molecules.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of the role of FABPs in cellular pathways.

Related Experiment Videos

  • Discussion of lipid-protein interactions in signal transduction.

    • Main Results:

    • FABPs are crucial for the transport and presentation of fatty acids within cells.
    • These proteins modulate the availability of fatty acids for signaling.
    • FABPs play a significant role in regulating fatty acid-mediated cellular responses.

    Conclusions:

    • Intracellular lipid-binding proteins, particularly FABPs, are essential regulators of fatty acid signaling.
    • Understanding FABP function is key to deciphering complex cell communication networks.
    • FABPs represent potential targets for modulating cellular processes involving fatty acids.