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[A decrease in the basal levels of serum pepsinogen I after H. pylori eradication]

D Boixeda1, J P Gisbert, T Vila

  • 1Servicio de Gastroenterología, Hospital Ramón y Cajal, Madrid.

Revista Clinica Espanola
|April 1, 1995
PubMed
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Eradicating Helicobacter pylori significantly lowers pepsinogen I levels in duodenal ulcer patients. This decrease offers a cost-effective, non-invasive method to monitor treatment success and gastritis resolution.

Area of Science:

  • Gastroenterology
  • Microbiology
  • Pathophysiology

Background:

  • Hyperpepsinogenemia is linked to duodenal ulcer development.
  • Helicobacter pylori infection is prevalent in duodenal ulcers.

Purpose of the Study:

  • To assess the impact of H. pylori eradication on basal pepsinogen I levels in duodenal ulcer patients.

Main Methods:

  • Prospective study of 86 duodenal ulcer patients.
  • Therapeutic regimens included antibiotics and acid suppressors.
  • Biopsy analysis for H. pylori and measurement of pepsinogen I levels before and after treatment.

Main Results:

  • H. pylori eradication led to significant histological improvement in the gastric antrum and corpus (p < 0.001).

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  • Pepsinogen I levels decreased significantly (p < 0.001) from 107.6 ng/ml to 79.7 ng/ml post-eradication.
  • No significant change in pepsinogen I levels was observed when eradication failed.

    • Conclusions:

    • H. pylori eradication significantly reduces basal pepsinogen I levels in duodenal ulcer patients.
    • Decreased pepsinogen I can serve as a non-invasive, low-cost indicator for monitoring therapy effectiveness and gastritis resolution.
    • This monitoring method provides early results and is cost-effective.