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[Evaluation of the hematologic autoanalyzer Coulter Maxm]
I Llompart1, M Vila, P Quetglas
1Servicio de Análisis Clínicos, Hospital de Son Dureta, Palma de Mallorca.
Sangre
|April 1, 1995
Summary
The Coulter MaxM autoanalyser offers a reliable automated leucocyte differential count (LDC) for laboratories, with good accuracy for most cell types but challenges with basophils. It provides a useful screening tool for white blood cell anomalies.
Area of Science:
- Hematology
- Clinical Chemistry
- Laboratory Automation
Background:
- Automated hematology analyzers are crucial for efficient and accurate blood cell counting.
- The Coulter MaxM is a newer autoanalyzer employing advanced technologies for cell analysis.
Purpose of the Study:
- To evaluate the performance of the Coulter MaxM autoanalyzer.
- To assess its accuracy in automated leucocyte differential counts (LDC).
- To determine the reliability of its morphologic anomaly detection.
Main Methods:
- Analyzed 2,016 blood samples using the Coulter MaxM.
- Assessed intra-assay and inter-assay inaccuracy, correlation with other systems (Coulter STKS, Technicon H1), and warning flag performance.
- Evaluated sample stability over time and the analyzer's processing speed.
Main Results:
- Acceptable intra-assay inaccuracy for most cell types, with notable exceptions for basophil counts.
- Optimal LDC correlation for neutrophils, eosinophils, and lymphocytes; variable correlation for other cell types and parameters.
- Warning flags identified suspect cells in 13.4% of samples, with higher rates for basophils and atypical lymphocytes. Acceptable sample stability for 24 hours under refrigeration.
Conclusions:
- The Coulter MaxM autoanalyzer is a valuable laboratory tool for performing 5-class LDC.
- It provides effective screening for white blood cell morphologic anomalies.
- Further attention may be needed for optimizing basophil and monocyte differentiation.