[Prostaglandins E in malignant stomach neoplasms]

Prostaglandins E (PGE) levels in gastric neoplasme have been studied radioimmunologically in 84 patients (aged 31-77) with tumors of different stages. A relationship between PGE level and main clinico-morphological features of tumor has been established. PGE concentration was shown to correlate with age, stage, histological pattern of tumor, cell differentiation and tumor infiltration. The highest PGE concentrations were observed in young patients, low-differentiated adenocarcino, a and pronounced tumor infiltration to adjacent tissues. No correlation has been found between PGE level and sex and tumor localization and size. The PGE level in the intact gastric mucosa was significantly lower in the body of the stomach than in its proximal and upper parts. The results of the investigation suggest a possible use of PGE antagonists for stomach cancer treatment.